association of periodontal diseases and liver fibrosis in patients with hcv and/or hbv infection

results of 351 patients, 76 patients (group 1) had a strong positive result for salivary occult blood test and 275 patients (group 2) had weak positive or negative test results. significant factors between the groups were obesity, level of ast, alt, ldh, alp, alb, d.bil, t.cho, afp, platelets (plt), iri, homa-ir, current interferon (ifn) treatment and the daily frequency of tooth brushing. between-groups analysis indicated that total protein (t.pro) level and liver fibrosis were significant factors. according to multivariate analysis, five factors were associated with periodontal disease as plt count below 80000, brushing teeth only once a day, current ifn treatment, aged 65 years or older and obesity. the adjusted odds ratios for these five factors were 5.80, 3.46, 2.87, 2.50 and 2.33, respectively, and each was statistically significant. twenty-eight saliva specimens had positive results for p. gingivalis with fima genotype types i to v. the prevalence of fima genotype ii was higher in 14 patients with liver cirrhosis or a history of hepatocellular carcinoma treatment (group b, 50.00%) than 14 patients with only hepatitis c (group a, 21.43%). background periodontal disease and systemic health are closely associated. however, there is no data supporting the association between periodontal disease and patients with liver diseases associated with hepatitis c virus (hcv) and/or hepatitis b virus (hbv) infection. conclusions periodontitis might be associated with progression of viral liver disease; hence, controlling oral disease is essential for the prevention and management of liver fibrosis. objectives the aim of this study was to evaluate the association between periodontitis and progression of liver diseases in patients with hcv and/or hbv infection. patients and methods in this retrospective study, 351 patients with hcv- and/or hbv-related liver diseases underwent screening for periodontal disease using the salivaster® salivary occult blood test from february 2010 to june 2014. furthermore, we examined the prevalence of fimbrillin (fima) genotype of porphyromonas gingivalis (p. gingivalis) in 28 hcv-infected patients visited at our hospital between january 2013 and june 2014. p. gingivalis with fima genotype with types i to v was further detected using a pcr method.